SELECTED PUBLICATIONS

References and Links to Recent Papers, complete publication list can be viewed here

BICOID-NUCLEOSOME COMPETITION SETS A CONCENTRATION THRESHOLD FOR TRANSCRIPTION CONSTRAINED BY GENOME REPLICATION

Degen EA, Croslyn C, Mangan NM, Blythe SA. Bicoid-nucleosome competition sets a concentration threshold for transcription constrained by genome replication. bioRxiv 2024.12.10.627802; doi: https://doi.org/10.1101/2024.12.10.627802.

LOCALIZATION OF THE DROSOPHILA PIONEER FACTOR GAF TO SUBNUCLEAR FOCI IS DRIVEN BY DNA BINDING AND REQUIRED TO SILENCE SATELLITE REPEAT EXPRESSION

Gaskill MM, Soluri IV, Branks AE, Boka AP, Stadler MR, Vietor K, Huang HS, Gibson TJ, Mukherjee A, Mir M, Blythe SA, Harrison MM. Localization of the Drosophila pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression. Dev Cell. 2023 Jul 17:S1534-5807(23)00324-6. doi: 10.1016/j.devcel.2023.06.010. Epub ahead of print. PMID: 37478844.

ZYGOTIC PIONEER FACTOR ACTIVITY OF ODD-PAIRED/ZIC IS NECESSARY FOR LATE FUNCTION OF THE DROSOPHILA SEGMENTATION NETWORK.

Soluri IV, Zumerling LM, Payan Parra OA, Clark EG, Blythe SA. Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network. Elife. 2020 Apr 29;9. doi: 10.7554/eLife.53916. PubMed PMID: 32347792; PubMed Central PMCID: PMC7190358.

QUANTITATIVE DISSECTION OF TRANSCRIPTION IN DEVELOPMENT YIELDS EVIDENCE FOR TRANSCRIPTION-FACTOR-DRIVEN CHROMATIN ACCESSIBILITY.

Eck E, Liu J, Kazemzadeh-Atoufi M, Ghoreishi S, Blythe SA, Garcia HG. Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility. Elife. 2020 Oct 19;9. doi: 10.7554/eLife.56429. PubMed PMID: 33074101; PubMed Central PMCID: PMC7738189.

RAPID DYNAMICS OF SIGNAL-DEPENDENT TRANSCRIPTIONAL REPRESSION BY CAPICUA.

Keenan SE, Blythe SA, Marmion RA, Djabrayan NJ, Wieschaus EF, Shvartsman SY. Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua. Dev Cell. 2020 Mar 23;52(6):794-801.e4. doi: 10.1016/j.devcel.2020.02.004. Epub 2020 Mar 5. PubMed PMID: 32142631; PubMed Central PMCID: PMC7161736.

CONCENTRATION DEPENDENT CHROMATIN STATES INDUCED BY THE BICOID MORPHOGEN GRADIENT.

Hannon CE, Blythe SA, Wieschaus EF. Concentration dependent chromatin states induced by the bicoid morphogen gradient. Elife. 2017 Sep 11;6. doi: 10.7554/eLife.28275. PubMed PMID: 28891464; PubMed Central PMCID: PMC5624782.

ESTABLISHMENT AND MAINTENANCE OF HERITABLE CHROMATIN STRUCTURE DURING EARLY DROSOPHILA EMBRYOGENESIS

Blythe SA, Wieschaus EF. Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis. Elife. 2016 Nov 23;5. doi: 10.7554/eLife.20148. PubMed PMID: 27879204; PubMed Central PMCID: PMC5156528.

ZYGOTIC GENOME ACTIVATION TRIGGERS THE DNA REPLICATION CHECKPOINT AT THE MIDBLASTULA TRANSITION

Blythe SA, Wieschaus EF. Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition. Cell. 2015 Mar 12;160(6):1169-81. doi: 10.1016/j.cell.2015.01.050. Epub 2015 Mar 5. PubMed PMID: 25748651; PubMed Central PMCID: PMC4359640.